Nano-topography sensing by osteoclasts

Nano-topography sensing by osteoclasts.

Bone resorption by osteoclasts depends on the assembly of a specialized, actin-rich adhesive 'sealing zone' that delimits the area designed for degradation. In this study, we show that the level of roughness of the underlying adhesive surface has a profound effect on the formation and stability of the sealing zone and the associated F-actin. As our primary model substrate, we use 'smooth' and '...

Zinc oxide nano-crystals assisted for carbon dioxide gas sensing; prepared by solvothermal and sonochemical methods

ZnO nanostructures of different methods and sizes were grown in a controlled manner using a simple hydrothermal and sonochemical technique. Controlling the content of concentration and temperature of the reaction mixture, spherical nanoparticles ZnO structures could be synthesized at temperatures 100-150 °C with excellent reproducibility in solvothermal and at different power and time in sonoch...

Cross-Presentation by Osteoclasts Induces

Effects of surface nano-topography on human osteoblast filopodia.

Anchorage-dependent cells growing over a substratum require stable adhesion areas on the surface for the next cellular activities. The adhesion is achieved by some contact points called focal adhesions. Because focal adhesions were distributed randomly, a trial to control the positions of focal adhesion with a specific order may cause interesting effects like as cytoskeleton rearrangement, whic...

Immersion scatterometry for improved nano-scale topography measurements